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Simethicone by itself is effective indefinitely with respect to in vitro antifoaming or antibubbling activity. However, simethicone antacid preparations must have an impermeable barrier between the simethicone and the antacid portion of the tablet to be stable with respect to this activity.

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WebMD provides information about interactions between Aluminum Hydroxide-Magnesium Hydroxide-Simethicone Oral and antacids-riociguat.

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alum & mag hydroxide-simethicone susp 400-400-40 mg/5ml 0.0520 20111202 20391231 ALUMINUM & MAGNESIUM HYDROXIDES SUSP 225-200 MG/5ML 0.0044 20111202 20391231 ALUMINUM HYDROXIDE GEL SUSP 320 MG/5ML 0.0093 20111202 20391231

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Aluminum Hydroxide; Magnesium Hydroxide; Simethicone: (Minor) Because antacids can alkalinize the urine, they can interact with urinary acidifiers, such as ascorbic acid. Frequent use of high doses of antacids should be avoided by patients receiving urinary acidifiers.

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48991003101835 Alum & Mag Hydroxide-Simethicone Susp 400-400-40 MG/5ML x x x x 48991003101840 Alum & Mag Hydroxide-Simethicone Susp 500-450-40 MG/5ML x x x x 48990002101820 Aluminum & Magnesium Hydroxides Susp 225-200 MG/5ML x x x x

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A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of impermeably coated famotidine granules for the treatment of gastric disorders and pharmacologically acceptable salts thereof; and a therapeutically effective amount of aluminum hydroxide or magnesium hydroxide wherein the oral dosage form has said coated famotidine …

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